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Mar 19, - Generally, no treatment for fifth disease is necessary for otherwise healthy children and adults who get it. If the rash itches, an antihistamine can be used. For those with joint pain, especially in adults, anti-inflammatory pain relievers such as ibuprofen can be helpful. Fifth disease (human parvovirus B19) is a common illness in children. At least half of North-American adults have been infected by parvovirus B19 and are.